Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Synthesis, characterization and biological evaluation of some novel heterocyclic compounds having sulphamido moiety

Author(s): Kokila. A. Parmar, Dhaval. J .Solanki, and Devang .J. Solanki

4-Amino-N-[4-(4-chloro-phenyl)-6-(3,4-dimethyl-phenyl)-pyrimidin-2-yl]- benzensulfonamide (2) was prepared by the hydrolysis of N-{4-[4-Chloro-phenyl}-6-(3,4-dimethyl-phenyl)-pyrimidin-2- ylsulfamoyl]-phenyl}-acetamide (1).It was on-facile condensation reaction with various aromatic aldehydes yields Schiff bases /anils/azomethines (3a-h). These anils on cyclo condensation reaction with thio glycolic acid (mercapto acetic acid) and thio lactic acid yields 4- thiazolidinoes (4a-h) and 5-Methyl 4-Thiazolidinones (5a-h) respectively. The newly synthesized compounds were evaluated for their antibacterial and antifungal activities


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