Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis, characterization and biological evaluation of some novel N1,N3-substituted 1-piperidin-4-yl-1,3-dihydro-2H-benzimidazol-2-one derivatives

Author(s): J. Sree Ram Babu, T. Ravi Sankar, K. Sudhakar Babu, J. Latha

Synthesis of some novel N1,N3-substituted 1-piperidin-4-yl-1,3-dihydro-2H-benzimidazol-2-one derivatives (7-10) were prepared from commercially available 1,2-phenylenediamine. Compounds (7-10) were tested for Gram positive: Streptococcus pyrogenes and Staphylococcus aureus. Gram negative: Escherichia coli, Pseudomonas arzenous, Proteus vulgaris, Salmonella typhi bacterial cultures. Compounds 7-10 were found to be highly active against Streptococcus pyogenes and Escherichia coli.


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