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Synthesis, characterization and biological evaluations of 2-(4-hydroxyaryl)-N'-[{5'-(substituted aryl)-furan-2'-yl}-methylidene]-ketohydrazides Schiff bases | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Synthesis, characterization and biological evaluations of 2-(4-hydroxyaryl)-N'-[{5'-(substituted aryl)-furan-2'-yl}-methylidene]-ketohydrazides Schiff bases

Author(s): Munendra Mohan Varshney*, Asif Husain and Versha Parcha

A novel series of 2-(4-hydroxyaryl)-N’-[{5’-(substituted aryl)-furan-2’-yl}-methylidene]-ketohydrazides have been designed and synthesized from the reaction of methyl-p-hydroxybenzoate 1, with hydraziane hydrate in anhydrous condition yielded 4-hydroxyphenyl-1-ketohydrazide 2, Further the resultant compound (2) was treated with different aromatic furfural aldehydes to yield substituted 2-(4-hydroxyaryl)-N’-[{5’-(substituted aryl)-furan-2’-yl}- methylidene]-ketohydrazides (3a-k) Schiff bases. The structures of these compounds were elucidated by IR, 1HNMR, Mass spectral data and CHN analysis. The title compounds 3a-k, have been evaluated in vitro antibacterial screening against Gram positive bacterial strains S. aureus, B. cereus , E. faecalis and S. epidermidis and Gram negative bacteria strains E. coli , S. typhi, S. dysenteriae and K. pneumoniae. The synthesized Schiff bases also showed significant anthelmintic activity against two species of earthworms (Pheritima posthuma and Perionyx excavates).


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