Research in Pharmaceutical Chemistry renders a vita l role in the discovery of newer therapeutic agents . Thiazines constitute an interesting class of heterocyclic com pounds with diverse biological and pharmaceutical p rofiles such as antimicrobial, anticonvulsant, anthelmintic, ant iviral, herbicidal, pesticidal, analgesic and anti- inflammatory activities. Moreover thiazine nucleus is a pharmaco phore of cephalosporin’s that occupy a very importa nt place in the field of antibiotics. Search for new molecules continues because of fast development of microbial resistance towards existing molecules and therefore new thiazi nes derivatives were synthesized with an aim to get potent antimicrobial agents. Acetyl acetone on Claisen-Sch midt condensation with various aromatic aldehydes i n presence of dilute sodium hydroxide afforded the correspondi ng chalcones derivatives. Further these compounds w ere subjected to cyclocondensation with thiourea, catal yzed by aqueous potassium hydroxide to form 2-imino-3,6- dihydro-2H- 1,3-thiazine derivatives. Characterizat ion of the synthesized compounds was done by using spectral techniques UV, IR, 1 H NMR & MASS. Antibacterial and antifungal screenin g was performed by cup plate method using the standards Ciprofloxacin and fluconazole r espectively.
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