Synthesis, characterization and biological study of new benzoxazole based sulphonamide derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Synthesis, characterization and biological study of new benzoxazole based sulphonamide derivatives

Author(s): Ramachandrula Krishna Kumar, Ramanayam S. K. Sharma, D. Ravi Kumar, Shrikanth H. Havele and S. V. Muraimohan Rao

Benzoxazoles are privileged organic compounds of medicinal significance, found in many natural products and are used in drug discovery programme. Eleven newly synthesized 4-amino-N-[1, 3-benzoxazole-2-yl] benzene sulphonamides derivatives were characterized by means of chromatography, IR, 1H-NMR and Mass spectral analysis.4-amino-N-[1, 3-benzoxazole-2-yl] benzene sulphonamides have significant biological activity in varied degrees. The investigation of anti-inflammatory activity revealed that the test compounds of 4-amino-N-[1,3- benzoxazole-2-yl] benzene sulphonamides showed favorable anti inflammatory activity at a dose of 30mg/kg bw. Among the titled compounds some were having potent antioxidant activity. Besides its use in medicinal chemistry, these are recognized as fluorescent probes such as anion and metal cation sensors, as photo chromatic agents and laser dyes.


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