GET THE APP

Synthesis, Characterization and Evaluation of Novel N-(1HBenzimidazol-2-Yl)-2-Isatinylidene-Hydrazinecarboxamide Derivatives as Anti-Inflammatory Agents | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Synthesis, Characterization and Evaluation of Novel N-(1HBenzimidazol-2-Yl)-2-Isatinylidene-Hydrazinecarboxamide Derivatives as Anti-Inflammatory Agents

Author(s): Gummadi Sridhar Babu, Nanam Rajani, Puttireddy S Malathy, Bethi Srinivas, Umasankar Kulandaivelu, Jupally Venkateshwar Rao

A series of isatin derivatives were synthesized by condensation of N-(1H-benzimidazol-2-yl)- hydrazine carboxamide with various isatin derivatives and evaluated for in vivo (rat paw edema) for their anti-inflammatory activity using carrageenan induced rat paw edema model. The synthesized compounds 6a-6h were characterized by spectral data (IR, 1H-NMR and mass) and elemental analysis. All the novel isatin derivatives exhibited mild to moderate activity. Compound 6b, 5-methyl isatin derivative exhibited better anti-inflammatory activity compared with control and other test compounds with percentage inhibition of 63.15


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 25868

Der Pharma Chemica received 25868 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry