GET THE APP

Synthesis, characterization and fungicidal activity of N-(5-oxo-3,7-diaryl-6,7-dihydro-5H-thiazolo [3,2,a] pyrimidin-6-yl) benzamide derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Synthesis, characterization and fungicidal activity of N-(5-oxo-3,7-diaryl-6,7-dihydro-5H-thiazolo [3,2,a] pyrimidin-6-yl) benzamide derivatives

Author(s): Shradha Pandey*, Prateek Pandey and Jagdamba Singh

2-Amino-4-aryl thiazoles and their derivatives have long been used as precursors for the synthesis of biologically active molecules. Therefore new antifungal compounds IV(a-e) have been synthesized incorporating 2-Amino-4-aryl thiazole. The title compounds were synthesized through isolable intermediates. All the synthesized compounds have been characterized by their elemental analysis, 1HNMR and Mass spectra. The synthesized compounds were evaluated in vitro for their antifungal activity against the test fungi by poisoned food technique; at 1000, 100 and 10 ppm using Czapek's agar medium. A standard commercial fungicide Dithane M-45 was also tested under similar conditions for comparison. It was found that all the compounds were antifungal active but amongst them IVd displayed fungicidal action comparable with that of commercial fungicide Dithane M-45.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Recommended Conferences
Google Scholar citation report
Citations : 23677

Der Pharma Chemica received 23677 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry