In the present investigation, a novel series of chalcones 2a–2e were synthesized by the clasein-schmidt condensation of various aldehydes with 3-acetyl-7-dimethylaminocoumarin in the presence of pyridine in ethanol which lead to the formation of new chalcones. The structures of these compounds were elucidated by, IR, 1H-NMR spectral data. The in vitro antibacterial activity of these compounds was evaluated against two Gram positive and two Gramnegative bacteria Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli and Pseudomonas aeruginosa by microdilution method and then the minimum inhibitory concentration (MIC) of these compounds was determined. The results showed that compounds 2d and 2e showed most promising antibacterial activity as compared to the antibiotics ciprofloxacin in (Tables 1).
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