Synthesis, characterization and in vitro biological evaluation of a series of 1,2,4-triazoles derivatives and triazole based schiff bases | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Synthesis, characterization and in vitro biological evaluation of a series of 1,2,4-triazoles derivatives & triazole based schiff bases

Author(s): Parjanya Kumar Shuklaa, Neetu Sonia, Amita Vermaa, Abhinav Kumar Jha

The 1,2,4-triazole nucleus is associated with diverse pharmacological activities such as antibacterial, antifungal, hypoglycemic, antihypertensive, analgesic, anti-inflammatory, anti-tumor, anti-viral, urease inhibition and many other properties. The increasing importance of 1,2,4-Triazoles as potent biologically active agents prompted authors to synthesize new series of 4-Amino-5-subsituted-3,4-dihydro-2H-[1,2,4]triazole-3-thiols. Different 2-(5- Mercapto-3-subsituted-1,5-dihydro-[1,2,4]triazol-4-yl)-isoindole-1,3-dione(6a-6e) and different Schiff bases 4-[(4- Dimethylamino-benzylidene)-amino]-5-subsituted-3,4-dihydro-2H-[1,2,4]triazole-3-thiol were synthesized from different 4-Amino-5-subsituted-3,4-dihydro-2H-[1,2,4]triazole-3-thiol and characterized by using spectral techniques 1H NMR, 13C NMR, FTIR, and mass spectrometry. All these compounds were screened for antimicrobial activity against Gram Positive, Gram Negative bacteria and fungal stains. Most of these compounds showed good antimicrobial activity. Compound 6a, 6b, 7c, 7a have good activity against P. aeruginosa, E. coli, B. subtilis, & B. cerus. Compound 7d & 7e found to be good active against P. areuginosa. Ciprofloxacin & Fluconazole were used as standard drug.


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