The 1,2,4-triazole nucleus is associated with diverse pharmacological activities such as antibacterial, antifungal, hypoglycemic, antihypertensive, analgesic, anti-inflammatory, anti-tumor, anti-viral, urease inhibition and many other properties. The increasing importance of 1,2,4-Triazoles as potent biologically active agents prompted authors to synthesize new series of 4-Amino-5-subsituted-3,4-dihydro-2H-[1,2,4]triazole-3-thiols. Different 2-(5- Mercapto-3-subsituted-1,5-dihydro-[1,2,4]triazol-4-yl)-isoindole-1,3-dione(6a-6e) and different Schiff bases 4-[(4- Dimethylamino-benzylidene)-amino]-5-subsituted-3,4-dihydro-2H-[1,2,4]triazole-3-thiol were synthesized from different 4-Amino-5-subsituted-3,4-dihydro-2H-[1,2,4]triazole-3-thiol and characterized by using spectral techniques 1H NMR, 13C NMR, FTIR, and mass spectrometry. All these compounds were screened for antimicrobial activity against Gram Positive, Gram Negative bacteria and fungal stains. Most of these compounds showed good antimicrobial activity. Compound 6a, 6b, 7c, 7a have good activity against P. aeruginosa, E. coli, B. subtilis, & B. cerus. Compound 7d & 7e found to be good active against P. areuginosa. Ciprofloxacin & Fluconazole were used as standard drug.
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