Benzothiazoles and pyrazoles moieties structurally have better pharmacological activity. A Series of 1-(7-chloro-6- fluoro-1,3-benzothiazol-2-yl)-3-methyl-1H-pyrazol-5-ol derivatives were synthesized in four phases containing different functional groups have been synthesized by condensing 7- Chloro-6-Fluoro-2-amino-Benzothiazole with hydrazine hydrate in the presence of ethylene glycol and conc. HCl. Then it was treated with ethylacetoacetate in presence of ethanol. In fourth phase 1-(7-chloro-6-fluoro-1,3-benzothiazole-2-yl)-3-methyl-1H-pyrazol-5-ol was treated with equimolar quantities of various substituted anilines like morph line, piperazine aniline presence of 30ml N,N- dimethyl formamide (DMF). The characterization of the compounds were confirmed on the basis of their spectral (IR, 1H-NMR and MASS) data. Further, they have been screened for their anti-microbial and anti-oxidant activities. Among the synthesized compounds. β-phenyl ethyl amine, m,o-toulidines and shows potent activity against the standard drug.
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