Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Synthesis, Characterization and Investigation of Biological Activities of Some New Zinc Complexes of Imidazo[4,5-f]1,10-phenanthroline Derivatives

Author(s): Vithal M Gugwad, Yogesh J Yadav, Parashuram A Jadhav, Anil A Ghanwat

The paper presents the synthesis of new complexes of Zn(II) with imidazole-based ligands L1-L4 {L1=2-p-tolyl-(1H-imidazo[4,5-f][1,10] phenanthroline), L2=2-p-chloro-benzene-(1H-imidazo[4,5-f][1,10]phenanthroline), L3=2-(3-indole)-(1H-imidazo [4,5-f][1,10]phenanthroline), L4=2-(3-7-azaindole)-(1H-imidazo[4,5-f][1,10]phenanthroline)} obtained from multi-component reaction of 1,10-phenanthroline-5,6-dione, aromatic/heterocyclic aldehydes and ammonium acetate. The newly synthesized ligands and complexes were characterized by combination of elemental analysis, 1H-NMR spectroscopy, 13C-NMR spectroscopy and mass spectra. The biological efficiency of the ligands and their complexes were examined against the growth of bacteria and fungi in vitro to evaluate their antimicrobial potential. The antibacterial and antifungal assay showed significant activity against the various bacterial and fungal organisms when compared with the standard antibiotics tetracycline and nystatin respectively.