In the present study, we have synthesized 1, 3, 4-thiadiazole derivatives because of their diverse biological and clinical applications. This created interest in researchers who have synthesized variety of thiadiazole derivatives and screened them for their various biological activities viz. in vitro antioxidant, anticancer, anti-HIV, anthelmintic, antimycobacterial, and anti-inflammatory, antidiabetic, antimicrobial, trypanocidal as well antimalarial activities. The results revealed that, some of tested compounds showed potent antioxidant activity. Amongst all the compound IIIA2 and IIIA4 have shown good scavenging activity. The remaining tested compounds were found weakly active.