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Synthesis, characterization and pharmacological activity of some new phthalimide derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Synthesis, characterization and pharmacological activity of some new phthalimide derivatives

Author(s): Omran Fhid*, Talal H Zeglam, Shaban EA Saad, Tariq Elmoug, Asma Eswayah, Majda Zitouni, Wafa Sdera, Ahmed A Edeep and Abdelhamed Ebzabez

Some novel appropriate amines linked to phthalimide moiety have been synthesized via microwave and reflux synthesizer. The phthalic anhydride was treated with various aliphatic amines (aminoethanol , aminopropanol, amino ethyl morphline, and some amino acids), the purity of the synthesized products were monitored by using TLC in an appropriate developing system. The structures of the new synthesized compounds were confirmed by using physical and spectral analysis. All the synthesized compounds were evaluated in vivo for analgesic activity by using standard experimental models. Compounds 2, 4 and 6 showed significant analgesic effect with hot plate and acetic acid inducer writhing tests in mice compared to the control group.


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