Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Synthesis, Characterization and Pharmacological Evaluation of New Mannich Bases with Coumarin Derivatives

Author(s): Kalyani G, Bethi Srinivas, Sastry KV, Vijaya Kuchana

In the current investigation, we have synthesized a series of new 4-({1-[(diethylamino)methyl]-1H-benzimidazol-2-yl}methyl)-2H-chromen-2-onederivatives have by the Mannich condensation reaction of 4-(1H-benzimadazole-2-ylmethyl)-2H-chromen-2-one(II) with different secondary amines and formaldehyde and the structures of compounds were characterized by Proton Nuclear Magnetic Resonance (1H-NMR), (Infra-red) IR and mass spectral analysis. The newly synthesized compounds are evaluated for their antibacterial activity against Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative) bacteria and also for anti-inflammatory potentials. Compounds 8 and 7 resulted in relatively higher antibacterial against S. aureus and E. coli respectively when compared to streptomycin. Dose level of 50 mg/kg of test compounds reported significantly higher anti-inflammatory activity when compared to dos level of 20 mg/kg. Moreover, compound 8 (50 mg/kg) resulted in similar anti-inflammatory activity when compared with celecoxib (20 mg/kg).


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