Synthesis, characterization and pharmacological evaluation of some novel quinoxaline derived chalcones | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X


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Synthesis, characterization and pharmacological evaluation of some novel quinoxaline derived chalcones

Author(s): Vijay Kotra, Karakavalasa Pradeep and R. Vasanthi

Quinoxalines derivatives were reported with wide range of biological activities. Hence it was planned to synthesize some novel series of quinoxalines derivatives. Orthopheneylene diamine was reacted with oxalic acid to form quinoxaline 2, 3 Dione. Quinoxaline-2, 3 (1H, 4H)-dione was chlorinated by using Phosphorousoxytrichloride in dimethyl formamide, to form 2, 3- dichloroquinoxaline. This dichloro compound subjected to reaction with 4 amino acetophenone in DMF, refluxed for 5 hours to form 1-(4-(3-chloroquinoxalin-2-ylamino) phenyl) ethanone. Similarly 1-(4-(3-chloroquinoxalin-2-ylamino) phenyl) ethanone then reacted with corresponding aromatic aldehydes to form quinoxaline derived chalcone by claisen Schmidt reaction. All the compounds were characterized by IR, 1H NMR and Mass spectroscopic data and the newly synthesized compounds were screened for anti bacterial, anti oxidant activities.


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