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Synthesis, characterization and pharmacological stu dies of some novel pyrimidine derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Synthesis, characterization and pharmacological stu dies of some novel pyrimidine derivatives

Author(s): Ashoka a , Balakrishna Kalluraya a* , Anish K., Manju N. and B. Sunil Kumar b

A novel series of ethyl 2-N-(aryl amino)-4-methyl-6 -phenylpyrimidine-5-carboxylate (4a-m) were synthesized from ethyl 2-chloro-4-methyl-6-phenylpyrimidine-5-carbox ylate (3) by reaction with appropriate anilines (a-m) . The structures of these compounds were established on t he basis of spectral and analytical data. These nov el compounds were screened for their antibacterial activity. The promising compounds 4a and 4h have been identified.


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