Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Synthesis, characterization and spectral studies of metal (II) complexes derived from benzofuran-2-carbohydrazide and 2-acetylthiophene Schiff's base

Author(s): M. B. Halli and Ravindra. S. Malipatil

The complexes of the type MLCl2, where M = Cu(II), ML2.2H2O,where M = Co(II), Ni(II) and ML2, where M = Zn(II), Cd(II) and Hg(II), L = [BCAT] Schiff’s base derived from reaction between benzofuran-2-carbohydrazide with 2-acetylthiophene. The ligand acts as bidentate by coordinating through carbonyl oxygen and azomethine nitrogen atoms. Structures have been elucidated on the basis of elemental analysis, conductivity measurement, magnetic properties, spectral studies like IR, 1H NMR, ESR and electronic spectral studies. On the basis of spectral characterization we proposed tentative structures for all these complexes. The antibacterial and antifungal activities of the ligand and their metal complexes have been screened by MIC method.


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