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Synthesis, characterization, antidiabetic and antioxidant activity of 1,3,4-oxadiazole derivatives bearing 6-methyl pyridine moiety | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis, characterization, antidiabetic and antioxidant activity of 1,3,4-oxadiazole derivatives bearing 6-methyl pyridine moiety

Author(s): Shyma P. C., Balakrishna Kallurayaa, Peethambar S. K and Vijesh A. M.

Three new series of 1,3,4-oxadiazole derivatives such as 2-[3-(6-methylpyridinyl)]-5-aryl-[1,3,4]-oxadiazole (3a-e), 2-[3-(6-methylpyridinyl)]-4-substitutedaminomethyl-[1,3,4]-oxadiazole-5-thione (5a-e) and 2-[3-(6-methyl pyridinyl)]-5-substituted benzylthio-[1,3,4]-oxadiazole (6a-e) were synthesized. Newly synthesized compounds were characterized by spectral and analytical studies. All the synthesized compounds were screened for their antidiabetic and antioxidant activity. The Mannich bases (5a-e) showed significant antioxidant activity comparable with that of the standard employed. Compounds 3d and 5a are showing good α-amylase inhibition activity and α- glucosidase inhibition activity against the standard.


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