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Synthesis, characterization, antimicrobial, DNA binding and cytotoxic studies of Co(II), Ni(II), Cu(II) and Zn(II) complexes of quinoline-adenine Schiff bases | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Synthesis, characterization, antimicrobial, DNA binding and cytotoxic studies of Co(II), Ni(II), Cu(II) and Zn(II) complexes of quinoline-adenine Schiff bases

Author(s): Pulin Nath and Shreedhar D. Dhumwad*

New transition metal complexes of Co(II), Ni(II), Cu(II) and Zn(II) with the Schiff bases derived from the condensation of 9H-purin-6-amine(Adenine) with 3-formyl-2-hydroxy quinoline (ADOH) and with 3-formyl-2- mercapto quinoline(ADSH) were synthesized and characterized by elemental analysis, molar conductance, magnetic susceptibilities, UV, IR, 1H-NMR, ESR and thermal studies. The elemental analysis of the complexes confirms [M(ADOH)2(H2O)2] and [M(ADSH)2(H2O)2] stoichiometry for Co(II), Ni(II), Cu(II) and Zn(II) complexes respectively. Both the ligands act as monobasic and didentate, coordinating through azomethine nitrogen, phenolic oxygen via deprotonation in ADOH and with thiolate sulphur in ADSH respectively. All the complexes exhibit octahedral geometry. The synthesized ligands and the metal complexes were screened for the antibacterial, antifungal and DNA Binding studies. The cytotoxic activity was carried by brine shrimp bioassay method for all the compounds. The results reveal that the metal complexes possess higher activity than the corresponding ligands. Among the metal complexes, Cu(II) complexes are found to be more potent than the other complexes.


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