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Synthesis, characterization, biological evaluation and docking studies of organo phosphorous pyrazole5-one derivatives of 1, 2, 4-triazoles and sulfones derivatives of sortase A staphylococcus inhibitors | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis, characterization, biological evaluation and docking studies of organo phosphorous pyrazole5-one derivatives of 1, 2, 4-triazoles and sulfones derivatives of sortase A staphylococcus inhibitors

Author(s): N. Sandhya Rani, G. V. Subbareddy, K. N. Jayaveeera, L. K. Ravindranath

New novel derivatives of diethyl (R)-1-(5-( Phenyl/4-methyl/4-methoxy/4-nitro/4-chloro/4-bromo/4-flouro benzyl sulfonyl)-4-(morpholino methyl)-4H-1,2,4-triazol-3-yl)methyl)-5-oxo-3-(trifluoro methyl)-4,5-dihydro-1H-pyrazol-4- yl)(4-(trifluoromethyl)phenylamino) methyl phosphonate (7a-g) containing various heterocyclic substituent’s were synthesized, characterized by elemental analysis,IR,1HNMR and 13CNMR spectra and evaluated for in antimicrobial and antifungal activity. Molecular docking studies were performed to calculate docking scores and to propose the binding mode of 1,2,4-triazoles and sulfones.


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