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Synthesis, characterization, biological evaluation and docking studies of pyrimidine-imidazole mannich base derivatives as transaminase bioainhibitors | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Synthesis, characterization, biological evaluation and docking studies of pyrimidine-imidazole mannich base derivatives as transaminase bioainhibitors

Author(s): G. Govindu, P. Raveendra Reddy, D. Rajesh and L. K. Ravindranath

The synthesis, as well as spectroscopic characteriz ation, biological evaluation and docking studies of a novel class of N'-((1-(piperidin/morpholin/ thiomorpholin/ meth ylpiperazine)-1H-imidazol-4-yl) methylene)-3-(4-sub stituted phenyl-[1,2,4] triazolo [4,3-c] pyrimidine-8-carboh ydrazide derivatives are described. All the synthes ized compounds were characterized byelemental analysis F TIR, 1 H-NMR, 13 C NMR, and Mass spectral data. All the synthesized compounds were exhibits antimicrobial a ctivities. Further the docking studies were carried out based on mycobacterial studies for the model compounds again st Transaminase BioA enzyme and the results found a re moderate.


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