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Synthesis, characterization of some novel coumarin derivatives and evaluation of their pharmacological activities | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis, characterization of some novel coumarin derivatives and evaluation of their pharmacological activities

Author(s): Alivelu Samala, Karthik G. and Santhosh Kumar Bagh

A series of new 3-[1-(6-Chloropyrimidin-4-yl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-2H-chromen-2-one(5a-j) were synthesized by the reaction between 4-aryl substituted-3-(4,5-dihydro-1H-pyrazol-3-yl)-2H-chromen-2-ones (4a-j) and 4,6-Dichloro pyrimidine in the presence of pyridine. The former was obtained by cyclisation of coumarin chalcone derivatives with hydrazine hydrate. The structures of the synthesized compounds have been established by IR and 1H NMR dada. Further they have been screened for anti-inflammatory and antibacterial activities.


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