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Synthesis, cytotoxicity and anti-mycobacterial activity evaluation of some newly substituted heterocyclic chalcones | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis, cytotoxicity and anti-mycobacterial activity evaluation of some newly substituted heterocyclic chalcones

Author(s): Ashok K. Singh*, Ravindra K. Singh, M. Arshad, Sahabjada, Deepa Keshari and Sudheer K. Singh

With the aim to access the biological activity, in the present study we have synthesized a series of substituted pyridyl chalcones (1a-1f) by condensing different p-substituted benzaldehyde with 2-Acetyl pyridine in dilute ethanolic potassium hydroxide solution at room temperature according to Claisen- Schmidt condensation. The chemical structures of all the compounds were assigned on the basis of elemental analyses, UV-Vis., IR, 1H NMR and mass spectral data. All the compounds were tested for their in vitro cytotoxic activity against human chronic myelogenous leukaemia cell line K562 and cell viability was evaluated by 3-(4,5-dimethylthiaazol-2-yl- 2,5diphenyltetrazoliumbromide(MTT)assay. All compounds indicated significant dose-dependent cytotoxicity in very low micro molar range (IC50 4.32-6.21μM). The anti-mycobacterial drug susceptibility testing (DST) performed against M.smegmatis and M.tuberculosis using microtiter plate resazurin reduction assay (REMA) with glycerol and acetate as two different carbon sources and results obtained were reported.


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