In the present study, a novel series of Pyrrole -2- carbohydrazide derivatives were synthesized and docking study was performed to rationalize the possible interactions between the synthesized compounds and active site. Pyrrole - 2- carbohydrazide derivatives were designed as Enoyl-acyl carrier protein reductase inhibitors. All compounds were screened for antimycobacterial activity against M.tuberculosis H37Rv using Microplate Alamar Blue Assay. Pyrazinamide (PZA) and Streptomycin were employed as the reference antimycobacterial agents. Among the series GS4 found to be most potent .