1,2,4-Triazine occupies a prominent position in the therapeutic front , possessing diverse range of biological activities. A series of novel derivatives of 1,2,4-Triazine were synthesized, characterized by means of spectral and chromatographic methods and their docking scores as an inhibitor of the enzyme CMet Kinase was calculated. The synthesized compounds were evaluated for their in vitro anti tumour activity by Trypan Blue exclusion method. The compound Ethyl [(5,6-diphenyl 3-(4-fluorophenyl)-2-(3-oxo-1,2,4-triazin- 2(3H)-yl)] prop-2-enoate (Va ) exhibited significant in vitro antitumour activity. Other derivatives like Ethyl [(5,6-diphenyl-3-(4-choro phenyl)-2-3-oxo-1,2,4-Triazine-2(3H)yl)] acetate (Vc), Ethyl [(5,6-diphenyl-3-(2-choro phenyl)-2-3-oxo-1,2,4-Triazine-2(3H)yl)] acetate. (Vh) and Ethyl [(5,6-diphenyl-3-(4-bromo phenyl)-2-3-oxo-1,2,4-Triazine-2(3H) yl)] acetate. (Vd) exhibited comparable anti-cancer properties. It can be concluded that 1,2,4-Triazine derivatives offers potential scope to drug research community for developing novel compounds of high therapeutic interest.