Synthesis, Docking Study of 2-(3-Substituted)-7-hydroxyl-4H-1-benzopyran-4-one Derivatives as Anti-Cancer agents | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X


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Synthesis, Docking Study of 2-(3-Substituted)-7-hydroxyl-4H-1-benzopyran-4-one Derivatives as Anti-Cancer agents

Author(s): Chavan Awinash, Chakre Rakshanda and Sabale Prafulla

Flavonoids are the natural phyto constituents widely distributed in plants originate in fruits, vegetables, grains, bark, roots, stems, flowers, tea and wine. Flavonoids have been recognized as secondary metabolites of plant, with marked biological significance such as Anti-inflammatory, Antioxidant, Anticancer and Antimicrobial activity. Hence, flavonoids are considered as an indispensable component in a variety of nutraceutical, pharmaceutical, medicinal and cosmetic applications with versatile health benefits. Recent researches on flavonoids received an added impulse with the discovery on anticancer by several mechanisms, but the most important mechanism is the inhibition of aromatase generating enzyme. In this research, attempt has been made to synthesize a novel series of synthetic flavones after molecular docking studies of compounds a-y. Novel flavones are synthesizing using 2, 4-dihydroxyacetophenone as starting material through Claisen-Schmidt Condensation Reaction. All the synthesized compounds were confirmed by their physicochemical properties. Novel flavone derivatives were assessing for anticancer activity by using SRB assay on MCF-7 cell line. Novel flavone derivatives were performed to establish correlation between biological activity and molecular properties. Among the synthesized compounds (a, b, c, k, l) showed good anticancer activity comparable to the reference drug Fadrazole. Thus, the conclusion can be made that the flavone moiety can exhibit a good anticancer activity.


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