Novel derivatives of Imidazo[1,2-a] pyrimidines(3a-3n) were synthesized by the ring opening of 4-Arylidine-2- Phenyl-Oxazole-5-Ones with 2-Amino Pyrimidines. The compounds obtained were identified and characterized by their physical, spectral and elemental analysis data. In vitro anti-proliferative activity of some of the synthesized compounds was carried out on A549 (Lung cancer) cell lines by employing MTT assay. In silico screening of these derivatives was carried out by molecular docking techniques using Schrodinger(Glide) and Auto dock softwares to find potent B-Raf Kinase inhibitors among the synthesized compounds. It was observed that compounds 3d and 3h with IC 50 values < 10 μM demonstrated good anti-proliferative activity on cell lines and are comparable with the respective docking G-Scores and mmGBSA values.