GET THE APP

Synthesis, Molecular docking and evaluation of antifungal activity of some benzyl benzimidazole derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Synthesis, Molecular docking and evaluation of antifungal activity of some benzyl benzimidazole derivatives

Author(s): Suvarna Katii, Preeti Bagul, Luketa Alai, Rasika Mahale, Ashok Pingle and Sanjay Wagh

A novel series of benzyl benzimidazoles substituted with piperazines were designed by study of active site of the fungal enzyme of cytochrome P 450 family lanosterol 14 α demethylase and synthesized. The molecular docking study of these compounds was performed at the active site of this enzyme. The synthesised compounds were charecterised by spectral analysis (IR,1H NMR).The screening of the synthesised compounds for in vitro antifungal activity revealed activity against c Candida albicans of some of the compounds comparable to that of ketoconazole.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 23677

Der Pharma Chemica received 23677 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry