GET THE APP

Synthesis of 1,4-Bis-(2,4-Dimethoxyphenyl)-2,3-Bis-(4-methoxybenzyl)-Butane-1,4-Dione | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Synthesis of 1,4-Bis-(2,4-Dimethoxyphenyl)-2,3-Bis-(4-methoxybenzyl)-Butane-1,4-Dione

Author(s): Ponnapali Veerabhadra Swamy, Bhaskara Venkata Prasad B, Balram B, Ram B and Taara B

Brackenin, an unusual biflavonoid which consists of two α, α’-coupled dihydrochalcones, has been isolated from Brackenridgea zanguebarica. To date it is the only naturally occurring compound in this class. Brackenin appears to posses the symmetrical structure of a meso compound and is composed of two dihydroisoliquiritigenin units linked by a carbon-carbon bond between the two α-carbon atoms. It represents the first biflavonoind in this class. The present paper describes the synthesis of 1,4-Bis-(2,4-dimethoxyphenyl)-2,3-bis-(4-methoxybenzyl)-butane-1,4- dione, a brackenin like molecule in a few high yielding steps utilizing green methodologies from readily available raw materials (Scheme 1 and Scheme 2).


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 25868

Der Pharma Chemica received 25868 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry