Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Synthesis of 1-amidoalkyl-2-naphthols by a three component reaction catalyzed by methane sulphonic acid

Author(s): V. Jhansi Rani, M. Suresh, P. Lavanya, K. Veena Vani, B. Nagarjuna and C. Venkata Rao

A three component one-pot condensation of 2-naphthol, ureas/amides and aldehydes catalyzed by methane sulphonic acid, under ambient conditions to afford 1-amidoalkyl-2-naphthols in excellent yields, with short reaction time, simple procedure, easy work-up and ecofriendly reaction condition.