GET THE APP

Synthesis of 1-(Methylsulfonylmethyl)-4-aryl -1H-pyrazole Derivatives Using Ruphos-Pd as Catalyst | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Synthesis of 1-(Methylsulfonylmethyl)-4-aryl -1H-pyrazole Derivatives Using Ruphos-Pd as Catalyst

Author(s): Bijivemula N Reddy, Reddy SM, Madhvesh Pathak

A novel serious of 1-(methylsulfonylmethyl)-4-aryl -1H-pyrazole derivatives were synthesized efficiently by Suzuki coupling of the 4-bromo-1-((methylsulfonyl) methyl)-1H-pyrazol- with various aryl boronic acids in the presence of Ruphos-Pd as a catalyst. The reaction is usually furnished within 3 min with good to excellent isolated yields. All synthesized compounds were characterized by spectral techniques, like Proton Nuclear Magnetic Resonance (1H NMR), 13C NMR and Liquid Chromatography–Mass Spectrometry (LC-MS) and also evaluate the antibacterial activity by disc diffusion method using two different bacteria’s Pseudomonas aeruginosa (Gram-negative) and Staphylococcus aureus (Gram-positive). Most of the synthesized compounds shown good antibacterial activity against the standard penicillin drug.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 25868

Der Pharma Chemica received 25868 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry