Synthesis of 1-(Methylsulfonylmethyl)-4-aryl -1H-pyrazole Derivatives Using Ruphos-Pd as Catalyst | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Synthesis of 1-(Methylsulfonylmethyl)-4-aryl -1H-pyrazole Derivatives Using Ruphos-Pd as Catalyst

Author(s): Bijivemula N Reddy, Reddy SM, Madhvesh Pathak

A novel serious of 1-(methylsulfonylmethyl)-4-aryl -1H-pyrazole derivatives were synthesized efficiently by Suzuki coupling of the 4-bromo-1-((methylsulfonyl) methyl)-1H-pyrazol- with various aryl boronic acids in the presence of Ruphos-Pd as a catalyst. The reaction is usually furnished within 3 min with good to excellent isolated yields. All synthesized compounds were characterized by spectral techniques, like Proton Nuclear Magnetic Resonance (1H NMR), 13C NMR and Liquid Chromatography–Mass Spectrometry (LC-MS) and also evaluate the antibacterial activity by disc diffusion method using two different bacteria’s Pseudomonas aeruginosa (Gram-negative) and Staphylococcus aureus (Gram-positive). Most of the synthesized compounds shown good antibacterial activity against the standard penicillin drug.


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