Synthesis of 2,3,5-trisubstituted-1,2,4-triazine-6- ones as potential antitumor agent | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X


süperbetin giriş

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

agariookey oyna istanbul okey


Synthesis of 2,3,5-trisubstituted-1,2,4-triazine-6- ones as potential antitumor agent

Author(s): Ayman S. Al-Hussaini, Elsherbiny H. Elsayed and Ema n M. Radwan *

2,3,5-trisubstituted-1,2,4-triazine-6-ones (2a,b) were synthesized by the cyclocondensation of oxazolinonederivatives (1) with semicarbazide and thiosemicarbazide. Acylation and condensation of triazine-6- one derivatives (2a,b) with acetic anhydride and 3-methoxy-2-hydroxybenzal dehyde yielded the corresponding N- acetyl derivatives (3a,b) and N-(3-methoxy-2-hydroxybenzylidene)amino derivat ives (4a,b). The structure of these synthesized compounds wascharacterized by 1 H-NMR, 13 C-NMR, Mass, IR and elemental analysis. All the synthesized 1,2,4-triazine-6-ones were tested for t heir cytotoxicity against HepG-2 cell line. Some of these compounds showed higher cytotoxicity activity than vinblastine standard


rokettube brazzers

Turkish dental care is known to be affordable compared to other countries. If you want an affordible dentist Turkey, check out periodonta. It is heavily recommended for dental patients visiting Turkey