Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Synthesis of (2-methyl-1,8-naphthyridin-3-yl)(4-methyl-3-arylpyrazolo[3,4- c]pyrazol-6(2H)-yl)methanone

Author(s): M. Randheer Kumar, S. Shiva Shankar E. Laxminarayana and M.Thirumala Chary*

Ethylacetoacetate reacts 2-Methyl-1,8-naphthyridin-3-hydrazide to in ethanol to give 2- Pyrazolone which on condensation with various aldehydes affords the related arylidine derivatives (3a-e). Cyclisation of arylidines form (4-Methyl-3-arylpyrazolo[3,4-c]pyrazol-6(2H)- yl)(1,8-naphthyridin-6-yl)methanone (4a-e).


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