In an attempt to find a new class of antimicrobial agents having anti-inflammatory activity, a series of thiophene containing Schiff base moiety were prepared via the reaction of ketone, 4-N-methyl piperidone with the propylcyanoacetamide using ammonium acetate/glacial acetic acid as an acidic catalyst with the arrangement of continuous removal of water followed by reacting starting compounds with substituted aryl aldehydes. These compounds were screened for their antibacterial activity against Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus), Gram-negative bacteria (Escherichia coli and Klebsiella pneumonia) and antifungal activity against (Aspergillus niger and Candida albicans) by using cup plate method. The results clearly revealed the potential antimicrobial and anti-inflammatory activity of all these piperidinothiophenes when compared with the standard drug Ampicillin, Miconazole and Ibuprofen. Structures of the newly synthesized compounds were established by elemental analysis and spectral data.
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