Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Synthesis of 3-((4-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl)methylamino)-2-arylthiazolidin-4-ones and 4-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl)-N-(5-aryl-1H-1,2,3-triazol-1-yl)methanamines
Author(s): Ajay Kumar R, Dayakar G, Sujatha I2-(chloromethyl)-1H-imidazo[4,5-b]pyridinereacts with hydrazine to form 1-((1H-imidazo[4,5-b]pyridin-2- yl)methyl)hydrazine (2), which on condensation with aromatic aldehydes converts in to 1-((4-(1H-imidazo[4,5- b]pyridin-2-yl)phenyl)methyl)-2-arylidenehydrazines (3a-f). Compounds 3a-f on reaction with thioglycolic acid and diazomethane lead to form 3-((4-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl)methylamino)-2-arylthiazolidin-4-ones (4af) and 4-(1H-imidazo[4,5-b]pyridin-2-yl)phenyl)-N-(5-aryl-1H-1,2,3-triazol-1-yl)methanamines respectively (5a-f).
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