Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis of 3,4-dihydropyrimidin-2(1H)-ones using camphor sulfonic acid as a catalyst under solvent-free conditions

Author(s): Srinivasulu Ramineni, bRavi Kumar Kannasani and cNageswara Rao Kalikinidi

DL-10-Camphorsulfonic acid (CAS. No- 5872-088-2) was found to be a convenient catalyst for the synthesis of 3,4- dihydropyrimidin-2-(1H)-ones through a one-pot three-component reaction of aldehydes, alkyl acetoacetate, and urea at 80οC under solvent-free conditions.


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