Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Synthesis of 3,5-diaryl-isoxazole-4-carbonitriles and their efficacy as antimicrobial agents

Author(s): Vasanth Kumar Govindappa, Jayaroopa Prabhashankar, Bi Bi Ahmadi Khatoon, Mylarappa B Ningappa, Ajay Kumar Kariyappa

Nitrile oxides generated in situ by the oxidative dehydrogenation of aromatic aldoximes (1a-g) undergo 1,3-dipolar cycloaddition reaction with 3-(4-methoxyphenyl)propiolonitrile (2) to afford the new cycloadducts 3-aryl-5-(4- methoxyphenyl)-isoxazole-4-carbonitriles (3a-g) in moderate yield. The new synthesized cycloadducts were tested for their antifungal and antibacterial activity.


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