GET THE APP

Synthesis of 5, 5?¢????-methylenebis (benzofuran-5,2-diyl))bis(phenylmethanone) and its phenylhydrazonoe, benzenesulfonate derivatives and their anti-inflammatory activity | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Synthesis of 5, 5?¢????-methylenebis (benzofuran-5,2-diyl))bis(phenylmethanone) and its phenylhydrazonoe, benzenesulfonate derivatives and their anti-inflammatory activity

Author(s): Bhookya Shankar, Pochampally Jalapathi, Sunitha Vianala and Karunakar Rao Kudle

Some novel anti-inflammatory entities derived from 5, 5’-methylenebis (benzofuran-5,2-diyl))bis(phenylmethanone, the structures of these compounds were elucidated by FTIR, 1H-NMR, 13C-NMR and Mass spectral analysis. Furthermore, all the compounds were evaluated for their activity using the carrageenan-induced rat paw edema method. Among the synthesized compounds, 4b, 4d, 4f, 6a and 6c showed significant (p < 0.01) reduction of rat paw edema volume, 4b & 6c showed the maximum anti-inflammatory activity after 24 h from the admin of the carrageenan compared to the standard drug, Ibuprofen.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 25868

Der Pharma Chemica received 25868 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry