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In the search for new antiviral drugs, we decided to synthesize new acyclovir derivatives which are widely used in the treatment of Herpes. This
work consisted of exploring the positon-7 of theophylline by alkyl halides, which led to compounds 3a-b. The introduction of chloroaryl and thioaryl
groups on the latter allowed to obtain compounds 5a-c and 7a-b. The chemical structures of all synthesized compounds were determined by 1 H, 13
C NMR and electron impact mass spectrometry.