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Synthesis of 7- (Ethylaryl) Theophylline DÚrivatives from Acyclovir | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis of 7- (Ethylaryl) Theophylline DÚrivatives from Acyclovir

Author(s): Sagne Jacques Akpa, Gbe Gondo Didier Diomande, Venance Martial Say, An├â┬ę Adjou

In the search for new antiviral drugs, we decided to synthesize new acyclovir derivatives which are widely used in the treatment of Herpes. This
work consisted of exploring the positon-7 of theophylline by alkyl halides, which led to compounds 3a-b. The introduction of chloroaryl and thioaryl
groups on the latter allowed to obtain compounds 5a-c and 7a-b. The chemical structures of all synthesized compounds were determined by 1 H, 13
C NMR and electron impact mass spectrometry.


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