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Synthesis of 7-carbethoxyamino-4-arylaminomethyl coumarins and their biological studies | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis of 7-carbethoxyamino-4-arylaminomethyl coumarins and their biological studies

Author(s): Priya M. Madalageri, Mahesh Kumar K., Sachin P. Ambekar, Soumya Kattimani, Masuku C. M.b and Arunkumar M. Shirahatti

As a part of our ongoing studies in developing new coumarin derivatives we describe the synthesis of novel 7- carbethoxyamino-4-(R) arylaminomethyl coumarins. The synthesized compounds were characterized by elemental, spectroscopic analysis (IR, Mass and NMR) and tested for their antibacterial and antifungal activity. The antimicrobial studies of the compounds (2a-p) showed significant activity against S. aureus and A. fumigatus. The compound (2f) was found to be more active against all the screened microbial.


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