GET THE APP

Synthesis of ?²-aminocarbonyl compounds catalyzed by 1-propylimidazolium trifluroacetoacetate | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Synthesis of ?²-aminocarbonyl compounds catalyzed by 1-propylimidazolium trifluroacetoacetate

Author(s): Janarthanan Porkodi, Sankaranarayanan Nagarajan, Susithra Selvam and Elango Kandasamy

A facile synthetic procedure has been reported for classical mannich reaction of aldehyde, acetophenone and aniline using catalytic quantity of 1-propylimidazolium trifluroacetoacetate. As a result, acetophenone undergo rapid reactions with a variety of halide substituted benzalaldehyde, methylbenzaldehyde, methoxybenzaldehyde, isopropylbenzaldehyde, nitrobenzaldehyde, halide substituted aniline, nitroaniline to produce β-aminocarbonyl compounds, in moderate to very good yields. Recovery of the products from the reaction mixture is very facile. Efficiency of the catalyst in terms of reusability is also discussed. The formation of the products was confirmed based on their H1 NMR and melting point.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Recommended Conferences
Google Scholar citation report
Citations : 23677

Der Pharma Chemica received 23677 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry