Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Synthesis of azetidinonyl substituted 1, 3, 4-thiadiazole-2-yl derivatives as antibacterial activity

Author(s): Joseph Valarmathy, Lazarus Samueljoshua, Govindasamy Rathinavel, Loganathan Senthilkumar

Some new 3-chloro-4-(phenyl substituted)-1-[5-pyridin-4-yl)-1,3,4-thiadiazol-2yl] azetidine 2- one derivatives (5a-e) have been synthesized by the reaction of INH(1) with potassium thio cynate. On further condensation with conc H2SO4 to form 5-(pyridine-4-yl)-1,3,4-thiazol-2- amine. The compound react with various aldehyde which on cyclo addition with chloroacetyl chloride and triethylamine in DMF. These compounds were characterized by their spectral data. The title compounds were found to be efficient antibacterial agents on evolution.


PDF

bornova escort karşıyaka escort osmangazi escort buca escort anne porno fetiş porno anal porno bartın escort burdur escort eskişehir escort escort izmir bursa escort porno escort bayan