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Synthesis of Benzo[b]furan and Benzo[b]thiophene-3-acetic Acids | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis of Benzo[b]furan and Benzo[b]thiophene-3-acetic Acids

Author(s): Pailla Umareddy, Veera Reddy Arava

Benzo[b]furan and Benzo[b]thiophene-3-acetic acids are prepared from the corresponding phenol or thiophenol by reacting with ethyl 4-chloro acetoacetate. The isolated acetoacetic ester derivatives were cyclized to give the respective ester of 3-acetic acids in good yields. Final hydrolysis resulted in 3-acetic acids in high yields.


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