Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis of bioactive furan derivatized pyrazole carboxamides: Studies on their antimicrobial and antioxidant activities

Author(s): Pavithra Gurunanjappa and Ajay Kumar Kariyappa

In search of new antimicrobial and antioxidant agents, a series of novel pyrazole carboxamides bearing furan moiety have synthesized by simple and assessable procedure. The method involves base catalyzed cyclocondensation reaction of chalcones 3a-e and semicarbazide hydrochloride 4 in ethanol under optimum temperature. The reaction yielded 3-(furan-2-yl)-4,5-dihydro-5-aryl-pyrazole-1-carboxamides 5a-g in good yields. The synthesized new compounds were characterized by spectral studies and elemental analysis, and were evaluated in vitro for their antimicrobial and antioxidant susceptibilities.


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