Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Synthesis of Biologically Active compound 1,4-dihydropyridine by using An Efficient and Versatile Silica supported MgO Catalyst
Author(s): Dipak R Tope, Shilpa L. Sangle*, Jyoti A. Agashe, Yogita R. Shelke and Ashok V. BorhadeA simple one pot synthesis has been developed for the synthesis 1,4-dihydropyridine using an efficient and reusable silica supported MgO solid catalyst by condensation of dimedone, ethyl acetoacetate, aldehyde and ammonium acetate in methanol as a solvent at room temperature. The reactions could be carried out under mild reaction conditions with very good yield of polyhydroquinoline, up to 92%. This catalyst could be recycled very easily, which makes this methodology environmentally benign.
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Citations : 25868
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