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Synthesis of Carbazole-1and3-acids by using Suzuki coupling followed by Cadagon Reductive cyclization | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis of Carbazole-1&3-acids by using Suzuki coupling followed by Cadagon Reductive cyclization

Author(s): Janardhanreddy Kanchani and M.C.S. Subha*

Using a Suzuki coupling followed by Cadagon reductive cyclization as a key steps, the first synthesis of 1-carboxylic acid carbazole has been achieved in 4 steps and in 65% overall yield. In the present work, this approach was applied to the total synthesis of carbazole alkaloids. This is the simple way to synthesise 9H-Carbazole-1-carboxylic acid and 9H-Carbazole-2-carboxylic acid.


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