Chalcones are the condensation product of acetophenone in combination with aromatic aldehydes in the presence of strong base. Chalcones are having prominent role in modern coordination chemistry. A series of chalcone derivatives were prepared by Claisen-Schmidt condensation of substituted 3-cinnamoyl-4-hydroxy-6-methyl-2-pyrones. The chalcone synthesized by base catalyzed condensation of 3-acetyl -6-methyl-2Hpyran- 2,4-(3H)dione (DHA) with different aromatic aldehyde. The synthesized compounds were characterized by IR and HNMR spectra’s. The derivatives were also used for the estimation of biological properties. From the study it was found that the synthesized compounds are efficient for further research work.