A vast array of fusing two heterocyclic rings namely 1,2,4-triazolo[34-b]thiadiazine derivatives having excellent pharmacological activity forms an invaluable part of the present inventions. A series triazolo thiadiazine derivative were synthesized by using aromatic acid and ethyl alcohol in alkali by treating aromatic acid with hydrazine hydrate and substituted acetophenone under reflux. The synthesised compounds were undergone spectral and elemental analysis. The active compound was found to be 4-(3-(2-(2,6-dichlorophenylamino)benzyl)-7H-[1,34]thiadiazin-6- yl)phenol equipotent as standard drug diclofenac. Presence of electronegative functional moieties as phenyl ring due to C2 position of thiazole ring possessing large hydrophilic for enhanced anti-inflammatory activity.