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Synthesis of hexahydro-6H-indolo[2,3-b]quinoxaline derivatives as potential antibacterial and anti-inflammatory agents | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis of hexahydro-6H-indolo[2,3-b]quinoxaline derivatives as potential antibacterial and anti-inflammatory agents

Author(s): Hajjaj H. M. Abdu-Allah, Samia G. Abdel-Moty and Helal F. Heta

In this study, hexahydro-6H-indolo[2,3-b]quinoxaline (1) was synthesized by condensation of isatin with 1,2- diaminocyclohexane. It was then reacted with methyl bromoacetate, hydrazine and finally condensed with selected carbonyl compounds to give the hydrazones 4-23. The new compounds have been characterized, screened for biological activity. Some of them showed significant antibacterial and anti-inflammatory activities. In particular, compound 20 showed interesting activities as anti-inflammtory and antibacterial.


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