Synthesis of Isocoumarins and its derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.


Synthesis of Isocoumarins and its derivatives

Author(s): Vijakumar L. Chavan and Rajendra R. Rane

3-methyl-1-oxo-1-H-2-benzopyran-4-carboxylic acid was synthesized in excellent yields by the reaction of homophthalic anhydride with acetyl chloride using pyridine as a catalyst, followed by rearrangement of 4-acetyl- 1H-2-benzopyran-1,3(4H)-dione with Conc. Sulphuric acid. Further 3-methyl-1-oxo-1H-2-benzopyran-4-carboxylic acid was derrivatised to various isoquinolones using ammonia and respective primary amines. It was also inferred the isoquinolones obtained were same when ammonia and other primary amines were treated with 3-methyl-1-oxo- 1-H-2-benzopyran-4-carboxylic acid, 4-acetyl-1H-2-benzopyran-1,3(4H)-dione, or 3-methyl-1H-2-benzopyran-1- one.


Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 25868

Der Pharma Chemica received 25868 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry